Open Access Article

Journal of Cell and Molecular Biology Research. 2022; 2: (1) ; 14-19 ; DOI: 10.12208/j.ijcmbr.20220004.

SIRTs in mitochondrial homeostasis and neurodegenerative diseases

作者: 戴宇莹 *, 司马健

中国药科大学 江苏南京

*通讯作者: 戴宇莹,单位:中国药科大学 江苏南京;

发布时间: 2022-12-09 总浏览量: 187


Sirtuins(SIRTs)蛋白家族是一类进化上高度保守的烟酰腺嘌呤二核苷酸(NAD+)依赖的去酰基酶, 多个成员在不同物种中都具有延长寿命的作用,被称为长寿蛋白家族。哺乳动物SIRTs共有7个成员(SIRT1-7)。研究证实:SIRTs是线粒体中的主要去乙酰基酶,通过多个代谢调节因子的去乙酰化以维持线粒体稳态。SIRT1是重要的核内脱乙酰基酶,其广泛参与线粒体稳态和其他多种生物过程,如凋亡、炎症和代谢。SIRT3主要定位在线粒体,并在线粒体稳态和代谢调节中发挥重要作用。线粒体稳态失衡严重影响神经元功能,并促进神经退行性类疾病的发生发展。因此,靶向改善线粒体稳态失衡和由其引起的细胞病理改变可能是干预神经退行性疾病的重要靶点。

关键词: SIRTs;线粒体稳态;神经元;神经退行性疾病


SIRTs are evolutionary conservedNAD+dependent deacylases. SIRTs activity has been implicated in life span extension.In mammals, seven SIRTs have been identified named as SIRT1-7.SIRTs are the maindeacetylases in mitochondria and act askey regulators for the deacetylation of metabolic agents to maintain mitochondrial homeostasis. SIRT1is a critical nuclear deacetylase that participates in a wide range of biological processes, such as apoptosis, inflammation and metabolism. SIRT3 islocated in mitochondria and involved in regulating mitochondrial homeostasis and metabolism. The imbalance of mitochondrial homeostasis triggersneuronal malfunction, which is a feature in the pathogenesis of neurodegenerative diseases. Thus, targetingimpairedmitochondrial homeostasis and the sequential pathological damage may be an important strategyfor intervention of neurodegenerative diseases.

Key words: SIRTs, Mitochondrial homeostasis, Neurons, Neurodegenerative diseases

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戴宇莹, 司马健 SIRTs蛋白在线粒体稳态及神经退行性疾病中的研究进展[J]. 细胞与分子生物学研究, 2022; 2: (1) : 14-19.