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Open Access Article

Journal of Cell and Molecular Biology Research. 2022; 2: (1) ; 26-35 ; DOI: 10.12208/j.ijcmbr.20220007.

Some progress, insights and thinking of Helicobacter pylori infection research
幽门螺杆菌感染研究的某些进展、管见与思考

作者: 廖远泉 *

安徽省泾县医院检验科 安徽泾县

*通讯作者: 廖远泉,单位:安徽省泾县医院检验科 安徽泾县;

发布时间: 2022-12-09 总浏览量: 417

摘要

幽门螺杆菌(Helicobacter pylori, H. pylori)感染已经在世界很多国家和地区广泛传播流行。其特定的螺旋形体型,细胞毒素相关A基因(Cag A)、空泡细胞毒素A基因(Vac A)等毒力因子是影响H. pylori定植与感染的相关致病因子。H. pylori感染在胃癌的发生发展中可能具有重要作用,但是,迄今尚未确认H. pylori感染是导致胃癌的主要因素。作者综述了相关致病因子及其致病机制的研究进展。值得关注的是亦有临床及实验研究者对于H. pylori感染因子及其感染机制、诊断与治疗等持有不同的认知或岐见。检验医学是一座将基础医学和临床医学连接起来的桥梁。贯彻落实我国重大传染病预防与控制措施, 检验医师应该与临床和预防医学工作者密切协作、共同关注当前H. pylori感染研究的这一重要课题。

关键词: 幽门螺杆菌;感染;流行病学;致病因子;细胞毒素;思考

Abstract

Helicobacter pylori (H. pylori) infection has spread widely in many countries and regions in the world. Its specific spirochete type, cytotoxin-associated A gene (Cag A), vacuolar cytotoxin A gene (Vac A) and other virulence factors are the relevant pathogenic factors that affect H. pylori colonization and infection. H. pylori infection may play an important role in the occurrence and development of gastric cancer, but so far it has not been confirmed that H. pylori infection is the main factor leading to gastric cancer. The authors reviewed the research progress of related pathogenic factors and their pathogenic mechanisms. It is worth noting that some clinical and experimental researchers hold different cognitions or disagreements about H. pylori infectious agents and their infection mechanisms, diagnosis and treatment. Laboratory medicine is a bridge connecting basic medicine and clinical medicine. To implement the prevention and control measures of major infectious diseases in my country, laboratory physicians should work closely with clinical and preventive medicine workers to pay attention to the important topic of current H. pylori infection research.

Key words: Helicobacter pylori; infection; epidemiology; causative agent; cytotoxin; think

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引用本文

廖远泉, 幽门螺杆菌感染研究的某些进展、管见与思考[J]. 细胞与分子生物学研究, 2022; 2: (1) : 26-35.