期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据:

Open Access Article

Journal of Cell and Molecular Biology Research. 2023; 3: (1) ; 1-4 ; DOI: 10.12208/j.jcmbr.20230001.

Research progress of deubiquitinating enzyme BAP1 and tumorigenesis and development
去泛素化酶BAP1与肿瘤发生发展的研究进展

作者: 邹萌萌, 吴照球 *

中国药科大学 江苏南京

*通讯作者: 吴照球,单位:中国药科大学 江苏南京;

发布时间: 2023-03-14 总浏览量: 1031

摘要

去泛素化酶主要通过水解泛素羧基末端的酯键,肽键或异肽键,将泛素分子特异性地从连接有泛素的蛋白或者前体蛋白上水解下来。去泛素化酶可能调节细胞增殖分化,抑制肿瘤细胞的生长。本文就去泛素化酶BAP1与肿瘤发生发展的研究进展进行了综述,包括乳腺癌,肝细胞癌,结直肠癌,胰腺癌和前列腺癌。

关键词: 去泛素化酶;BAP1;肿瘤

Abstract

Deubiquitination enzymes specifically hydrolyze ubiquitin molecules from ubiquitin-attached proteins or precursors by hydrolyzing ester, peptide or isopeptide bonds at the carboxy-terminus of ubiquitin. Deubiquitination enzyme may regulate cell proliferation and differentiation and inhibit the growth of tumor cells. This review reviews the research progress of the deubiquitination enzyme BAP1 and the development of tumors, including breast cancer,hepatocellular carcinoma, colorectal cancer, pancreatic cancer and prostate cancer.

Key words: Deubiquitinating enzymes, BAP1, cancer

参考文献 References

[1] QIN J, ZHOU Z, CHEN W, et al. BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5[J]. Nat Commun, 2015, 6:8471.

[2] KOMANDER D, CLAGUE M J, URBE S. Breaking the chains: structure and function of the deubiquitinases[J]. Nat Rev Mol Cell Biol, 2009, 10(8):550-63.

[3] LIM K H, SONG M H, BAEK K H. Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint[J]. Cell Mol Life Sci, 2016, 73(7):1439-55.

[4] JENSEN D E, PROCTOR M, MARQUIS S T, et al. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression[J]. Oncogene, 1998, 16(9):1097-112.

[5] CARBONE M, YANG H, PASS H I, et al. BAP1 and cancer[J]. Nat Rev Cancer, 2013, 13(3):153-9.

[6] ESTAVOYER B, MESSMER C, ECHBICHEB M, et al. Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases[J]. J Biol Chem, 2022, 298(8):102198.

[7] BREKKEN R A. Loss of BAP1 Leads to More YAPing in Pancreatic Cancer[J]. Cancer Res, 2020, 80(8):1624-1625.

[8] SHAHRIYARI L, ABDEL-RAHMAN M, CEBULLA C. BAP1 expression is prognostic in breast and uveal melanoma but not colon cancer and is highly positively correlated with RBM15B and USP19[J]. PLoS One, 2019, 14(2):e0211507.

[9] TANG J, LI Y, SANG Y, et al. LncRNA PVT1 regulates triple-negative breast cancer through KLF5/beta-catenin signaling[J]. Oncogene, 2018, 37(34):4723-4734.

[10] ZARRIZI R, MENARD J A, BELTING M, et al. Deubiquitination of gamma-tubulin by BAP1 prevents chromosome instability in breast cancer cells[J]. Cancer Res, 2014, 74(22):6499-508.

[11] YAN L, YU M C, GAO G L, et al. MiR-125a-5p functions as a tumour suppressor in breast cancer by downregulating BAP1[J]. J Cell Biochem, 2018, 119(11):8773-8783.

[12] KALIRAI H, DODSON A, FAQIR S, et al. Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing[J]. Br J Cancer, 2014, 111(7):1373-80.

[13] PENA-LLOPIS S, VEGA-RUBIN-DE-CELIS S, LIAO A, et al. BAP1 loss defines a new class of renal cell carcinoma[J]. Nat Genet, 2012, 44(7):751-9.

[14] CHEN X, HUANG A, WANG Y, et al. BRCA1-associated protein 1 serves as a tumor suppressor in hepatocellular carcinoma by deubiquitinating and stabilizing PTEN[J]. Am J Cancer Res, 2021, 11(5):2044-2061.

[15] MAYO S C, PAWLIK T M. Current management of colorectal hepatic metastasis[J]. Expert Rev Gastroenterol Hepatol, 2009, 3(2):131-44.

[16] DUFFY M J, VAN DALEN A, HAGLUND C, et al. Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use[J]. Eur J Cancer, 2007, 43(9):1348-60.

[17] JIA Y, GUO M. Epigenetic changes in colorectal cancer[J]. Chin J Cancer, 2013, 32(1):21-30.

[18] TANG J, XI S, WANG G, et al. Prognostic significance of BRCA1-associated protein 1 in colorectal cancer[J]. Med Oncol, 2013, 30(2):541.

[19] PERKAIL S, ANDRICOVICH J, KAI Y, et al. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice[J]. Nat Commun, 2020, 11(1):3018.

[20] LEE H J, PHAM T, CHANG M T, et al. The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma[J]. Cancer Res, 2020, 80(8):1656-1668.

[21] DENG R, GUO Y, LI L, et al. BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN[J]. Mol Oncol, 2021, 15(1):279-298.

[22] PARK C M, LEE J E, KIM J H. BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation[J]. Genetics and Molecular Biology, 2020, 43(2).

引用本文

邹萌萌, 吴照球, 去泛素化酶BAP1与肿瘤发生发展的研究进展[J]. 细胞与分子生物学研究, 2023; 3: (1) : 1-4.