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当前位置：细胞与分子生物学研究 > 2023年 3卷 (1)期

Open Access Article

Journal of Cell and Molecular Biology Research. 2023; 3: (1) ; 30-44 ; DOI: 10.12208/j.jcmbr.20230006.

Application and prospects of stem cell technology in tissue repair and regenerative medicine
干细胞技术在组织修复和再生医学中的应用与前景

作者： 李森 *

河北医科大学河北石家庄

*通讯作者：李森,单位：河北医科大学河北石家庄；

发布时间: 2023-12-20 总浏览量: 729

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摘要

干细胞技术在组织修复和再生医学中扮演着至关重要的角色，其独特的自我更新能力和多向分化潜力为治疗各种疾病提供了新的策略。本文综述了干细胞技术的基本知识，包括干细胞的分类、特性以及分离和培养技术。重点探讨了干细胞在皮肤、骨骼、软骨、心脏和神经组织修复中的应用，以及在再生医学范畴内的应用前景。此外，通过案例研究，本文展示了干细胞技术在实际临床治疗中的成功实例，同时也指出了当前干细胞应用面临的挑战和伦理问题，包括技术的安全性、治疗的可及性以及成本问题。未来，随着技术的进步和伦理法规的完善，干细胞技术有望在组织修复和再生医学中发挥更大作用，为广泛的疾病治疗提供新的解决方案。本文通过深入分析和讨论，强调了继续研究和发展干细胞技术的必要性以及对未来治疗方法的积极前景。

关键词： 干细胞技术；组织修复；再生医学

Abstract

Stem cell technology plays a crucial role in tissue repair and regenerative medicine, and its unique self-renewal ability and multidirectional differentiation potential provide new strategies for treating various diseases. This article reviews the basics of stem cell technology, including the classification and properties of stem cells as well as isolation and culture techniques. The focus is on the application of stem cells in skin, bone, cartilage, heart and neural tissue repair, as well as their promising applications in the context of regenerative medicine. In addition, through case studies, the paper demonstrates successful examples of stem cell technology in actual clinical treatments, while also pointing out the current challenges and ethical issues facing stem cell applications, including the safety of the technology, the accessibility of the treatment, and the cost. In the future, with the advancement of technology and the improvement of ethical regulations, stem cell technology is expected to play a greater role in tissue repair and regenerative medicine, providing new solutions for a wide range of disease treatments. Through in-depth analysis and discussion, this paper highlights the need for continued research and development of stem cell technology and the positive outlook for future therapeutic approaches.

Key words： Stem cell technology; tissue repair; regenerative medicine

参考文献 References

[1] 朱迅.干细胞技术:全球医疗的下一个重大突破口[J].药学进展, 2019(6):3.

[2] 刘晓东.干细胞技术在抗衰老中的应运用研究[J].中文科技期刊数据库(全文版)医药卫生, 2022(3):3.

[3] 刘昊,张永刚.骨组织工程的研究应用与进展[J]. 2022(2).

[4] 于修成.干细胞技术的临床应用与研究[C]//中华医学会第四次生殖医学学术年会暨首届中国—东盟生殖医学论坛.0[2024-03-14].

[5] 邓海燕,刘馨,缪着,等.干细胞治疗心脏病的研究进展[J].中华细胞与干细胞杂志：电子版, 2020, 10(5):6.

[6] 祝思路,罗丹.干细胞衰老的研究进展[J].基础医学与临床, 2022, 42(8):4.

[7] Arshi A, Petrigliano F A, Williams R J, et al. Stem cell treatment for knee articular cartilage defects and osteoarthritis[J]. Current reviews in musculoskeletal medicine, 2020, 13: 20-27.

[8] Parizadeh S M, Jafarzadeh‐Esfehani R, Ghandehari M, et al. Stem cell therapy: A novel approach for myocardial infarction[J]. Journal of Cellular Physiology, 2019, 234(10): 16904-16912.

[9] Abdul Kareem N, Aijaz A, Jeschke M G. Stem cell therapy for burns: story so far[J]. Biologics: Targets and Therapy, 2021: 379-397.

[10] Relaix F, Bencze M, Borok M J, et al. Perspectives on skeletal muscle stem cells[J]. Nature communications, 2021, 12(1): 692.

[11] Serowoky M A, Arata C E, Crump J G, et al. Skeletal stem cells: insights into maintaining and regenerating the skeleton[J]. Development, 2020, 147(5): dev179325.

[12] Arshi A, Petrigliano F A, Williams R J, et al. Stem cell treatment for knee articular cartilage defects and osteoarthritis[J]. Current reviews in musculoskeletal medicine, 2020, 13: 20-27.

[13] Sui B D, Hu C H, Liu A Q, et al. Stem cell-based bone regeneration in diseased microenvironments: challenges and solutions[J]. Biomaterials, 2019, 196: 18-30.

[14] Brown C, McKee C, Bakshi S, et al. Mesenchymal stem cells: Cell therapy and regeneration potential[J]. Journal of tissue engineering and regenerative medicine, 2019, 13(9): 1738-1755.

[15] 杨天云,王长谦.间充质干细胞及相关衍生治疗方法促进心肌梗死后心肌修复[J].国际心血管病杂志, 2022, 49(3):4.

[16] 陶梦丹刘妍.人多能干细胞在帕金森综合症治疗与研究中的作用[J].中山大学学报:医学科学版, 2022, 43(2):173-180.

[17] 左远胜,陶海鹰.间充质干细胞治疗脊髓损伤机制的研究进展[J].颈腰痛杂志, 2023, 44(3):481-484.

[18] Park S J, Kim R Y, Park B W, et al. Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction[J]. Nature communications, 2019, 10(1): 3123.

[19] Su X, Wang T, Guo S. Applications of 3D printed bone tissue engineering scaffolds in the stem cell field[J]. Regenerative therapy, 2021, 16: 63-72.

[20] Päth G, Perakakis N, Mantzoros C S, et al. Stem cells in the treatment of diabetes mellitus—Focus on mesenchymal stem cells[J]. Metabolism, 2019, 90: 1-15.

[21] Triolo T M, Bellin M D. Lessons from human islet transplantation inform stem cell-based approaches in the treatment of diabetes[J]. Frontiers in endocrinology, 2021, 12: 636824.

[22] Zhou G P, Jiang Y Z, Sun L Y, et al. Therapeutic effect and safety of stem cell therapy for chronic liver disease: a systematic review and meta-analysis of randomized controlled trials[J]. Stem Cell Research & Therapy, 2020, 11: 1-19.

[23] Arutyunyan I V, Fatkhudinov T K, Makarov A V, et al. Regenerative medicine of pancreatic islets[J]. World Journal of Gastroenterology, 2020, 26(22): 2948.

[24] Fioretta E S, Motta S E, Lintas V, et al. Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity[J]. Nature Reviews Cardiology, 2021, 18(2): 92-116.

[25] Kronemberger G S, Matsui R A M, de Castro G A S, et al. Cartilage and bone tissue engineering using adipose stromal/stem cells spheroids as building blocks[J]. World Journal of Stem Cells, 2020, 12(2): 110.

引用本文

李森, 干细胞技术在组织修复和再生医学中的应用与前景[J]. 细胞与分子生物学研究, 2023; 3: (1) : 30-44.

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