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Open Access Article

Journal of Cell and Molecular Biology Research. 2021; 1: (1) ; 33-41 ; DOI: 10.12208/j.ijcmbr.20210007.

Advances in basic research of induced pluripotent stem cells in prevention and treatment of chronic complications in diabetes mellitus.
诱导多能干细胞在糖尿病慢性并发症防治中基础研究进展

作者: 王婉乔, 李彦欣*,

上海交通大学医学院附属上海儿童医学中心,血液肿瘤科,国家卫生健康委员会儿童血液肿瘤重点实验室 上海

上海交通大学医学院附属上海儿童医学中心,血液肿瘤科, 国家卫生健康委员会儿童血液肿瘤重点实验室 上海

*通讯作者: 李彦欣,单位:上海交通大学医学院附属上海儿童医学中心,血液肿瘤科, 国家卫生健康委员会儿童血液肿瘤重点实验室 上海;

发布时间: 2021-10-20 总浏览量: 330

摘要

近年来,再生医学和干细胞治疗技术发展迅速,利用诱导多能干细胞(induced pluripotent stem cells, iPSCs)技术,能够将已经分化成熟的体细胞逆转为早期未分化的多能干细胞,再经各种细胞因子处理诱导其定向分化为终末目的细胞,其过程类似于胚胎细胞的生长发育过程。将此技术运用于糖尿病视网膜病变、糖尿病心肌病变、糖尿病神经病变以及糖尿病肾病等糖尿病常见慢性并发症的防治研究,并逐渐探索适用于临床的方法,开始成为糖尿病干细胞治疗领域的一大研究热点。研究显示,此种干细胞疗法在细胞和实验动物水平获得了积极的结果,并开始探索应用于临床。因此,笔者拟就iPSCs在糖尿病慢性并发症应用方面的基础研究进展进行概括并提出展望。

关键词: 诱导多能干细胞;糖尿病;细胞治疗;糖尿病视网膜病变;糖尿病心肌病;糖尿病周围神经病变;糖尿病肾病

Abstract

In recent years, the rapid development of regenerative medicine and stem cell therapy techniques has enabled the reversal of mature somatic cells into early undifferentiated pluripotent stem cells byusing induced pluripotent stem cells (iPSCs).After treatment with various cytokines, the cells were induced to differentiate into terminal target cells, which was similar to the growth and development process of embryonic cells.Applying this technology to the prevention and treatment of diabetic retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic nephropathy and other chronic complications of diabetes, and gradually exploring the method suitable for clinical use, has become a major research hotspot in the field of diabetic stem cell therapy.The stem cell therapy has shown positive results at the cell and laboratory animal levels, and is beginning to be explored for clinical use.Therefore,I intend to summarize the basic research progress ofiPSCs in the application of chronic complications in DM and put forward the prospect.

Key words: Induced Pluripotent Stemcells; Diabetes Mellitus; Diabetic Retinopathy; Diabetic Cardiomyopathy; Diabetic Peripheral Neuropathy; Diabetic Nephropathy

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引用本文

王婉乔, 李彦欣, 诱导多能干细胞在糖尿病慢性并发症防治中基础研究进展[J]. 细胞与分子生物学研究, 2021; 1: (1) : 33-41.